Neuroendocrine cancer day 2021. Noutăți | Endo-ERN | European Reference Network on Rare Endocrine Conditions

Human adipose-derived stem cells: definition, isolation, tissue-engineering applications S. Nae, I. Bordeianu, A. Stancioiu, N. Antohi Recent researches have demonstrated that the most effective repair system of the body is represented by stem cells - unspecialized cells, capable of self-renewal through successive mitoses, which have also the ability to transform into neuroendocrine cancer day 2021 cell types through differentiation.

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The discovery of adult stem cells represented an important step in regenerative medicine because they no longer raises ethical or legal issues and are more accessible. Only instem cells isolated from adipose tissue were described as multipotent stem cells. Adipose tissue stem cells benefits in tissue engineering and regenerative medicine are numerous.

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Development of adipose tissue engineering techniques offers a great potential in surpassing the existing limits faced by the classical approaches used in plastic and reconstructive surgery. Adipose tissue engineering clinical applications are wide and varied, including reconstructive, corrective and cosmetic procedures.

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  • Neuroendocrine transdifferentiation of prostate carcinoma cells and its prognostic significance Madalina Marcu, E.

Nowadays, adipose tissue engineering is a fast developing field, both in terms of fundamental researches and medical applications, addressing issues related to current clinical pathology or trauma management of soft tissue injuries in different body locations.

Corresponding author: Sorin Nae, MD; e-mail: naedaniel gmail. Margaritescu, A. Stepan, V. Patrascu, C. Georgescu, Daniela Cernea, Daniela Dumitrescu Invasive lobular carcinoma ILC is the second most common type of invasive breast cancer, having distinct morphologically but also prognostic and therapeutic features.


This type of breast cancer shows a higher rate of multiple metastases with a more frequent axillary-lymph-node involvement. Regardless of histopathological or molecular subtype, the statistical tests proved that for ILC, the highest D lymphatic microvessels density LMVD was in sto marlit r peritumoral areas. In classical subtype, the LMVD values were positively correlated with the degree of tumor differentiation and pTNM clinical stages and when these cases were classified based on the molecular criteria the highest recorded values were found in the luminal B subtype.

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This immunoprofile suggests the existence of a tumor type-specific lymphangiogenesis that may have certain prognostic and therapeutic implications. Man, Cl. Marginean, O. Cotoi Purpose: To evaluate the correlations between the pro-inflammatory interleukins IL-6 and IL-8 and the anthropometric measurements in malnourished vs. Results: From children, The mean age was 5.

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IL-6 and IL-8 mean neuroendocrine cancer day 2021 were 2. By statistically comparing IL-6 in malnourished group vs.

Care va fi efectul asupra legislației fiecărei țări membre UE, cum văd pacienții această oportunitate, care sunt lipsurile sistemului de sănătate românesc în ceea ce privește managementul afecțiunilor oncologice, cum pot fi implementate prevederile Planului European în practica românească? La aceste întrebări au răspuns reprezentanții asociațiilor de pacienți din România pentru Revista Politici de sănătate. Pandemia ne-a demonstrat, încă o dată, că nu avem politici sanitare bine stabilite, mai ales în domeniul cancerului, unde un plan național ar fi prevăzut toate aspectele sociale, juridice, sanitare și toate procedurile necesare pentru o astfel de stare de urgență.

Ciurea, Daniela Cernea, C. Georgescu, O. Cotoi, V. Patrascu, H. Parvanescu, D. Popa, V. Parvanescu, Raluca Niculina Ciurea, R. The nodular and infiltrative-morpheaform are the most common BCC types in the head and neck region and together with the micronodular subtypes are the most aggressive tumors, because of their tendency to infiltrate the deep subcutis, muscles and even bones.

To explain the local aggressive behavior and their metastatic potential, many studies have been performed to identify the molecular determinants implicated in BCC tumor progression.

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For this reason, we investigated the immunohistochemical expression of Neuroendocrine cancer day 2021, MMP and beta-catenin expression in six metatypical, eight infiltrative-morpheaform, six micronodular and five superficial facial BCCs. For all three markers, the tumor reactivity varied with the histological type.

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The highest reactivity was observed in metatypical subtype, especially at the level of areas with squamous cells differentiation. The lowest reactivity was recorded in micronodular and superficial BCC subtypes. Regardless histological subtype, the tumor reactivity was higher at the advancing edge and additional a strong stromal reaction was noticed for all investigated markers peculiar in fibroblasts, inflammatory cells and endothelial cells. All these data proved the utility of CXCR4, MMP and beta-catenin immunohistochemical neuroendocrine cancer day 2021 in BCCs both for identification of high-aggressive tumors and to develop novel more efficient therapeutic strategy for these patients by targeting these biomarkers.

Electrical conduction system apoptosis in type II diabetes mellitus S. Rusu, F. Pop Even though apoptosis is known to be associated with various cardiovascular pathologies, its presence in cardiac nodal tissue in adults was giardien mensch diagnostik scarcely researched.


Cardiomyocyte apoptosis was associated with diabetic cardiovascular pathology. Our main objective was to test whether programmed cell death is present in nodal tissue in type II diabetes mellitus and, if present to characterize it.

The study was designed as a qualitative one. We used autopsy samples of hearts from 10 patients 56 to year-old, male to female ratiopositive for type II diabetes mellitus.

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Samples from sinoatrial and atrioventricular nodes were stained with Hematoxylin-Eosin. Nodal tissue in all samples was characterized by diffuse interstitial fibrosis and chronic ischemic lesions; nuclear damage and foci of irreversible ischemic necrosis intermingled with isles of relatively morphologically normal myocytes.

Sinoatrial and atrioventricular nodes were caspase-3 and -9 positive, and also cathepsin-B-positive, suggesting an overlap between apoptotic and necrotic mechanisms.

Central area of the sinus node seemed to have the most severe lesions. Estrogen and progesterone receptor expression in the mammary gland tumors M. Moise, M. Buruian, C. Motoc In the primary mammary malignant tumors, neuroendocrine cancer day 2021 in situ carcinoma, it is recommended the carrying out of immunohistochemical diagnosis neuroendocrine cancer day 2021 the estrogen ER and the progesterone receptors PR.

We have studied the ER and the PR expression in malignant tumors, trying to identify the corresponding phenotypes according to the presence of these tumors.

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We have carried out a study on a total number of 80 carcinomas, divided into two groups: the first one constituted of 54 cases of carcinomas on which we had clinical data, and another group, constituted of 26 cases of mammary carcinoma, where no clinical data was available. We have observed that the values and the distribution of the ER and PR taken from the biopsies made in the patients with mammary carcinoma are influenced by the age and menopausal status.

The involvement of growth differentiation factor 5 GDF5 and aggrecan in the epithelial-mesenchymal transition neuroendocrine cancer day 2021 salivary gland pleomorphic adenoma Anca Stefania Enescu, Cl. Margaritescu, Monica Mihaela Craitoiu, Aurelia Enescu, Stefania Craitoiu Pleomorphic adenoma is the most common salivary gland tumor with annual incidence of The histogenesis of salivary gland pleomorphic adenoma is still unclear.

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One concept sustains the existence of an epithelial-mesenchymal transitions EMT process in pleomorphic adenomas by which neoplastic epithelial cells transdifferentiate into mesenchymal cells and leading to tissue heterogeneity from this salivary gland neoplasia.

Here we investigate by immunohistochemistry the expression of growth differentiation factor 5 GDF5 and aggrecan in 15 cases of salivary gland pleomorphic adenomas. We found that both markers were present in normal salivary gland, mainly in the cells that line striated and intercalated ducts suggesting their involvement in the morphogenesis of this duct system.